The E2 test measures the level of estradiol, the main form of estrogen in the blood.
Estradiol is produced mainly by the ovaries in women, and in smaller amounts by the testes in men and adrenal glands in both sexes.
It plays an important role in:
Women: Menstrual cycle regulation, ovulation, and preparing the uterus for pregnancy.
Men: Supporting sperm production and bone health.
Evaluate infertility or menstrual irregularities.
Monitor ovulation induction during fertility treatment.
Check for menopause or premature ovarian failure.
Monitor hormone replacement therapy.
Investigate low sex drive or infertility.
Detect possible hormone imbalances.
Evaluate early (precocious) or delayed puberty.
(Varies by lab, menstrual cycle phase, age, and gender)
| Group | Estradiol (pg/mL) |
|---|---|
| Women (follicular phase) | 20 – 350 |
| Women (mid-cycle peak) | 150 – 750 |
| Women (luteal phase) | 30 – 450 |
| Postmenopausal women | < 20 |
| Men | 10 – 50 |
| Children | < 10 before puberty |
| High Estradiol | Low Estradiol |
|---|---|
| Ovarian tumors | Menopause |
| Hyperthyroidism | Premature ovarian failure |
| Liver disease | PCOS (may also cause high in some cases) |
| Certain hormone therapies | Poor ovarian function |
| Pregnancy (normal) | Turner syndrome |
No strict fasting needed.
For fertility evaluation, women are usually tested on day 3 of their menstrual cycle.
Inform your doctor about hormone therapy or birth control pills (they can affect results)
Same Day*
